Hill runners and cyclists
Sustained climbing loads the calves and Achilles heavily and asks a lot of the glutes and hip extensors; sustained descending is eccentric work that can leave quads sore in a way flat mileage often doesn't, and it can be demanding on the knees over time. Vestavia athletes tend to show up with one or the other, sometimes both in the same week.
We treat that as a chain rather than a hotspot: calves and the posterior lower leg, then the hip and glute complex that either supports or abandons them. Descending soreness in particular often responds well to a session followed by a cold plunge, which many clients find takes the edge off a heavy training weekend.